The 21st International Congress of the Iranian Association of Endodontists will be held from January 15 to 18, 2024, at the Milad Tower in Tehran. In addition to focusing on proper root canal treatment principles, the 21st International Congress of the Iranian Association of Endodontists will pay special attention to related sciences, enabling participants to plan comprehensive treatment for their patients. The theme of this year’s congress is “Innovation in Endodontics: Bridging Experience and Science,” and we will explore practical innovations in this field. Hands-on workshops, which are always a highlight of our congresses, will be held this year with special care and planning to ensure that our esteemed colleagues can benefit from them in the best possible way. We have also added a new section focused on clinical endodontics. In this section, participants will watch various videos about root canal treatment and, engage in discussions, questions, and answers with top specialists in each field. We hope that with the cooperation of all our esteemed professors and the enthusiastic participation of our colleagues, we will, as always, hold a beneficial congress and that the results of these efforts will lead to improving the quality and scientific nature of treatments for our dear patients.